" The Melbourne trial is the world’s largest single site for the A4 study, which has about 1000 participants globally. "
The Australian site of the ‘A4 Study’ is recruiting

Researchers from the University of Melbourne are asking Victorians to join a world first drug trial testing the efficacy of an experimental Alzheimer’s disease treatment.

The Anti-Amyloid Treatment in Asymptomatic Alzheimer’s Disease study (i.e. the A4 study) is seeking 400 healthy adults aged 65 to 85, who do not have any known memory problems. The Melbourne trial is the world’s largest single site for the A4 study, which has about 1000 participants globally.

It is important to note that the A4 study is not setting out to reverse the symptoms of Alzheimer’s disease but aims to assess whether this experimental treatment can slow down memory loss caused by Alzheimer’s disease pathology.

The treatment, an anti-amyloid therapy, targets amyloid proteins, which can build up in the brain to form toxic amyloid plaques that damage and kill the brains’ cells, causing symptoms such as memory loss.

Interested but not sure if you would be eligible? You can take a pre-screener eligibility test here – http://a4study.org/screener.

Eligible participants who show high levels of amyloid (based on a brain PET scan) will either receive a monthly dose of the experimental anti-amyloid treatment, or a placebo. Volunteers with low levels of amyloid may take part in a separate observational study, and may also be included as control participants.

Professor Colin Masters, who leads the A4 study in Australia, says researchers hope one of the new anti-amyloid therapies will slow or even halt Alzheimer’s disease-related early damage to the brain.

“This study is about predicting who is at risk and how fast they will decline. This is the first attempt at stopping the disease before it starts and before it progresses to full blown dementia,” Professor Masters said.

Recruitment will close at the end of 2016 and first results are expected in 2020. To enrol in the study or to find out more you can phone 1800 443 253 or visit  www.florey.edu.au/research/mental-health/a4-anti-amyloid-in-asymptomatic-alzheimer-s

 Posted: April 29th, 2016
Discussion

Linda said:

Went to the Florey lecture this week on Brain Matters andam interested in joining your research program

Dementia Daily Team said:

Hi Russell, It might be a good idea to contact the people who are conducting the trial about this. They may be able to answer your question. You can also contact us on the National Dementia Helpline on 1800 100 500 if you have any other questions. Thank you and all the best, Sarah - The Dementia Daily Team

Russell said:

Why only Victoria ? I have recently been diagnosed as having brain shrinkage, and am a diabetic type 2, I would like to join your research program.

Russell Walters said:

Why only Victoria ?, I have brain shrinkage recently diagnosed, am diabetic type 2, and would very much like to be included in your study ??

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Call the National Dementia Helpline: 1800 100 500